“As long as you keep doing it, the goddess of fortune will take care of you.” After ten years of Johnson and Johnson’s tenure, Qin Hao has been convinced of this statement on the road to entrepreneurship.
The brain is amazing, controlling all the activities related to people’s language, movements, emotions and so on. Out of this original curiosity, Qin Yu chose neurology when he chose a major. However, there is always a gap between academics and reality. “When you really get into clinical patients, you find that this is a painful thing – many clinical patients cannot be cured.” Qin said, “especially stroke patients. There is no corresponding special medicine, the only thing that can be done is to try to make the condition no longer worse.”
We spend a lot of thoughts to locate a qualitative diagnosis, to understand what subtypes the disease belongs to, and in the end there is no corresponding treatment. This kind of diagnosis and treatment is unacceptable to Qin Lan. She is not willing to stay in the hospital to be a doctor who can only diagnose but can’t cure the disease. She wants to do more about “treating the disease”.
Find the market pain point: 40 million potential patient groups, 2000 neuro-interventional surgeons
In China, there are currently only about 2,000 neuro-interventional surgeons, but there are 40 million potential cerebrovascular disease patients, and there are 5 million new stroke patients each year. In the face of so many potential patients, limited medical resources are difficult to cope with.
Taking intracranial aneurysms as an example, the prevalence of the disease abroad is about 2% to 3%, but in China, the prevalence of the adult population is as high as 7%, which is much higher than cancer. For patients, if the intracranial aneurysm does not rupture, it is not aware of its own disease, but once it ruptures, the mortality rate is as high as 1/3, and the mortality rate of rebleeding is more than 1/2. It is a veritable “intraceramic time.” bomb”.
You can’t wait until you have had bleeding and then go to first aid. You should cure the disease before it breaks. A safe and effective treatment is neurological intervention. However, neurological intervention surgery not only lacks professional doctor resources, but also complicated surgery, and it is difficult for low-grade doctors to learn quickly.
The traditional doctor learning mode belongs to the “master with apprenticeship”. However, neuro-invasive surgery is no more than traditional open surgery. It is impossible to visually see the anatomy of the lesion and the operation technique during the operation. It can only be described by the two-dimensional image on the DSA screen and the language of the doctor’s master. I am groping for growth. The intricate three-dimensional form of the cerebral blood vessels and the surgical techniques that the apprentices receive are not only unintuitive, but also obscure. Wanting to be a mature neuro-interventional surgeon is a long process.
Create a strong joint intelligence: AI assisted doctors to perform neurological interventional surgery to improve the red line of the medical system
In September 2016, Qianglian Zhichuang was founded. The person in charge of marketing is Liu Wenzhe, an old partner of Qin Yu who has worked for many years. Liu Wenzhe was the national sales manager of the Department of Neurosurgery of Johnson & Johnson Group. He has 15 years of experience in the sales of neurological medicines and consumables. He has won the annual sales champion and the annual sales manager of China.
Yang Guangming, the company’s chief technology officer, is a doctor of engineering at Tsinghua University. He has more than 10 years of experience in medical device imaging equipment and software development management, and is also a senior engineer in medical imaging.
Qin has worked in Johnson & Johnson for nearly 10 years, with 5 years of sales experience, 4 years and a half of national professional education and national marketing management experience, has won the Asia Pacific sales champion and many annual sales champions in China. So far, Qin has been working hard for 15 years in the field of neurological intervention. The establishment of Qianglian Zhichuang is based on the strong pain points of clinical treatment, and strives to upgrade the status quo of the entire industry.
In the neurological interventional surgery, if the microcatheter can be shaped, the difficulty of surgery is reduced by 50%. This is a well-recognized surgical difficulty in the industry, and it is also the strong pain point selected by Qianglian Zhichuang. At the beginning of research and development, I tried to shape the microcatheter by 3D printing. However, only the 3D cerebrovascular tube was printed, but it was not enough. First, the difficulty of solving the three-dimensional shape design of the microcatheter and the shaping needle was solved. The second is the printing process. It takes a long time to use itself as an auxiliary means of surgery, and timeliness is not guaranteed, especially in emergency surgery.
Qianglian Zhichuang needs to find the optimal solution—using a combination of surgical simulation algorithms, image algorithms, deep learning algorithms, etc., and relying on computer-aided methods to achieve microcatheter shaping. This means that Qianglian Zhichuang urgently needs experts in the field of artificial intelligence to join. “As long as you keep doing it, the goddess of fortune will take care of you.” The goddess of fortune really took care of Qin.
Coincidentally, Qin Hao discovered that his high school classmate, Dr. Yin Yi, is a big coffee in the field of medical artificial intelligence. During his time at the University of Iowa, he has been studying the AI algorithm for medical images, with more than a decade of medical depth. Learning algorithm experience, many of his research and development results have obtained FDA certification, and led the team to complete the world’s first three-dimensional breast cancer detection products based on deep learning technology. With the strong participation of India, Qianglian Zhichuang jumped to the top level in the world at the algorithm level.
“If artificial intelligence can assist doctors in achieving a full-diagnosis process, the red line of the entire medical system will be improved. That is to say, patients who go to the primary hospital or the top three hospitals can get the top doctors of the top three hospitals. Medical services. We hope to improve the overall level of diagnosis and treatment of grassroots hospitals and young doctors through this intelligent assistance method,” said Qin Tong, founder of Qianglian Zhichuang.
Unified Data Standards: Focus on hemorrhagic and ischemic strokes, providing doctors with surgical planning and consumables selection
Stroke, commonly known as “stroke”, is an acute cerebrovascular disease characterized by brain tissue damage caused by blood inflow into the brain. It is divided into ischemic and hemorrhagic stroke. Ischemic stroke refers to blood vessels in the brain. Blockage causes blood to flow into the brain. Hemorrhagic stroke refers to a sudden rupture of blood vessels in the brain that prevents blood from flowing into the brain. According to data from the Lancet, from 1990 to 2017, stroke was the first leading cause of death in China, with an overall mortality rate greater than 60%.
Qianglian Zhichuang wants to make a product line about stroke, and can’t avoid establishing relevant data standards. Take the CT data of early cerebral infarction as an example. At the earliest, Qianglian Zhichuang made a CT labeling of cerebral infarction by contacting senior doctors in the top three hospitals, but found the same CT map, and the lesions marked by different doctors have Access. After more than two months of double-blind labeling, it was found that the labeling overlap between doctors was very low, and different doctors had very different CT judgments on early cerebral infarction.
What is the real standard? The Qianglian Zhichuang team is thinking about this issue. “For early cerebral infarction, whether they are senior or low-grade doctors, their knowledge of nuclear magnetic data is unified, and the labeling is naturally the same. Nuclear magnetic data is the gold standard.” Qin Qi told the reporter, ” We select CT maps with corresponding nuclear magnetic data, and then accurately plot the CT map based on the nuclear magnetic data.”
At present, through the brain artificial intelligence diagnosis and treatment platform of Qianglian Zhichuang, it is possible to solve a major surgical difficulty for the neurointerventional doctor – microcatheter shaping. Without the aid of artificial intelligence platform, doctors need to restore the three-dimensional picture of the brain blood vessels in the brain through a complex two-dimensional map of the brain blood vessels, and then find the lesions, and conceive the three-dimensional shape of the microcatheter suitable for treatment in the brain, and finally Perform micro-catheter shaping operation. The “shaping conception” process in the brain is difficult to teach and prone to bias. If artificial intelligence is used, the computer can directly simulate the microcatheter path, giving the optimal solution of the three-dimensional shape of the microcatheter head. Qianglian Zhichuang has conducted more than 80 clinical trials, and 80% of the microcatheters have been put into place at one time. In the past, the doctor had to take more than two hours to complete the operation. With AI assistance, it was completed in half an hour.
For patients with acute cerebral infarction, every 3 seconds of treatment delay means that 100,000 brain cells die permanently, and doctors are fighting for the patients. Even a neurosurgist who has been in the experience for more than a decade can take more than a minute to judge the patient’s scan, and Qianglian Zhichuang’s stroke artificial intelligence diagnosis and treatment platform only takes 2.2 seconds, and the speed is greatly improved. Interventional thrombectomy for acute cerebral infarction is of great significance.
In addition, Qianglian Zhichuang is continuing to develop new functions for stroke artificial intelligence diagnosis, covering new stroke diseases, providing doctors with disease screening, automatic diagnosis, treatment decision-making, surgical planning, consumable selection and simulation. , patient follow-up and a series of intelligent assistance for the entire treatment process.
Full-care assistant: get two rounds of financing, protect life with technology
The business model of Qianglian Zhichuang, in addition to the layout and sales in the form of image workstations for auxiliary diagnosis and auxiliary treatment, can also be in the form of an artificial intelligent medical treatment platform, which is charged according to the annual service fee or by example, while providing surgical support. Treatment supplies and services.
Up to now, the company has completed the Angel Wheel investment of Anlong Medical Fund and the A-round investment of Lenovo Star and Tuojin Capital, and plans to start the B round of financing in the second half of this year. The proceeds from the financing will be used for clinical trials prior to the launch of the product and for marketing after the listing.
“Along the way, we will find that our mission is to use AI to empower medical care and protect our lives with science and technology. We not only want to be China’s largest intelligent diagnosis and treatment platform for stroke, but our vision is to be the world’s leading intelligent diagnosis and treatment platform for stroke. “Qin Wei sees the future of Qianglian Zhichuang in this way.”